SARM – Ligandrol (LGD-4033)

Over the past few years, the popularity of substances like SARMs has proliferated. Today they are much more popular than anabolic steroids. Why? Because SARMs are an equally effective but much safer way to increase exercise capacity. If someone cares about getting maximum effects, such a person will probably decide to use ligandrol (LGD-4033). Next to RAD-140, it is the most potent compound from the SARMs group. How does ligandrol affect the body, and what do you need to know about it?

A brief history of ligandrol

At the end of the twentieth century, the American company Ligand Pharmaceuticals joined research conducted worldwide. Their goal was to find new substances that could help treat patients suffering from osteoporosis and muscle atrophy. In time, Ligand announced its success. It was the successful synthesis of a compound named ligandrol (LGD-4033) in its honor.

Over time, ligandrol was subjected to numerous studies. Researchers at Boston Medical Center confirmed that LGD-4033 can help increase dry muscle mass. In addition, researchers observed a noticeable increase in strength in people taking ligandrol. This, in turn, led to a massive increase in interest in the compound. In the meantime, the Ligand Pharmaceuticals company started having severe problems. Because of this, its shareholders decided to sell the rights to produce the developed substance. Eventually, they were acquired by Viking Therapeutics, which changed the name of ligandrol to VK5211. Notably, the group continues to conduct research on the effects of the described compound. In 2016, the phase 2 clinical trial results involving patients who are post-hip surgery were released. The results of these studies proved that ligandrol helped patients increase muscle mass.

Ligandrol in sports

The increased interest in ligandrol also attracted the attention of the International Anti-Doping Agency (WADA). Its members were concerned that professional athletes might benefit abnormally by taking LGD-4033. This, in turn, prompted their decision to ban ligandrol. British representatives of WADA have made it clear that LGD-4033 UK is a compound not allowed in professional sports.

However, such restrictions necessarily do not affect the capabilities of people who participate in amateur sports. Clearly, the properties of ligandrol began to interest strength sports enthusiasts primarily. Demand turned out to be so great that over time manufacturers of dietary supplements started to launch products containing LGD-4033. After just a short time, it turned out to be an excellent decision. Sales of such preparations exceeded the wildest expectations. To this day, LGD-4033 SARMs remain at the top of its category in terms of popularity.

What benefits does ligandrol provide?

Ligandrol is most talked about in the context of increasing muscle mass. At the end of the day, this effect was supposed to play a vital role in the use of such supplementation. However, later studies have shown that LGD-4033 has a much broader impact on the body. Apart from stimulating androgen receptors, ligandrol also exhibits anti-catabolic effects. This obviously enhances anabolic processes and, at the same time, increases the obtained results. What is more, LGD-4033 is said to have an equally positive effect on our skeletal system. Researchers mention, among other things, an increase in the level of bone mineralization in people taking ligandrol.

Ligandrol is undoubtedly a very potent anabolic. Tests showed that even minimal doses of a few milligrams provided beneficial effects in terms of muscle growth!

LGD-4033 dosage

Based on the above information, even small amounts of LGD-4033 will provide specific benefits. However, some people who take this compound rely on slightly higher dosages. The golden mean is usually a dosage of 10 milligrams per day. This can therefore be taken as a benchmark. Notably, women and beginners should start with smaller doses. Only later, as your tolerance grows, can you gradually increase your intake.

LGD-4033 cycling effects

LGD-4033 cycle effects can be impressive. Of course, such results are, to some extent, individual because they depend, among other things, on the predisposition of a given body. Nevertheless, even in the low effectiveness of supplementation, people taking ligandrol can count on gains of 2 kilograms of dry muscle mass per cycle. If one combines LGD-4033 with other SARMs, this value may increase significantly!

As for the cycles themselves, they have pretty standard assumptions. The shorter process involves taking LGD-4033 daily for about 6-8 weeks. After that time, a break will be required.

Finally, it is worth mentioning that when supplementing with ligandrol, following the described rules is extremely important. LGD-4033 may cause side effects associated with a decrease in testosterone levels and an increase in estradiol. However, such products are observed mainly with higher doses. Therefore, the described supplementation should be conducted with caution.


Ligandrol is a very potent compound belonging to the SARMs group. Using even small doses of LGD-4033 has been correlated with a visible increase in lean muscle mass. In addition, ligandrol may have a positive effect on bone health by increasing bone mineralization levels. In terms of safety, LGD-4033, when used as directed, generally does not cause side effects. However, it is still a good idea to carefully monitor your body during the cycle and react to any possible problems. The recommended regimen for taking ligandrol is to use 10 milligrams per day for about 6-8 weeks. Ligandrol can be safely combined with most SARMs.