Hi-Tech Pharmaceuticals Estrogenex 2nd Generation – Hormonal Support & Estrogen Modulator (90 Tablets)

Estrogenex 2nd Generation by Hi-Tech Pharmaceuticals is a next-level hormonal support formula designed to help balance testosterone to estrogen ratios, especially during or after aggressive supplement protocols. With a proprietary blend based on the brand’s patented Extend-Rx™ Technology, this product aims to support natural testosterone while helping to reduce the influence of estrogenic pathways.

This is not just a basic estrogen blocker — it combines anti-aromatase agents, testosterone-support compounds, and phytonutrients to provide a more comprehensive hormone management solution.

This action has become the hallmark of Estrogenex from Hi-Tech Pharmaceuticals. At one time, it was a trendy supplement. For this reason, the second Generation of this preparation, which was recently released on the market, has attracted great interest. But what active substances were included in its composition? Here is a list of the essential ingredients:

– 3 -Androstanediol (5 55-androstane-, 17-diol) – This compound can have a powerful anabolic effect on the body. The impact of such action can be seen, for example, in terms of more intensive protein synthesis, which leads to significantly more impressive muscle gains. Additionally, this compound has the potential to increase testosterone levels in the body.

– Chrisin 99% – Many athletes, particularly those who are serious about their training, appreciate the use of supplements. Among such compounds is chrisin, a flavonoid found, for example, in passion flowers. Chrisin can support the production of testosterone and act favourably on the body’s anabolism. For this reason, it could not be missing from the second Generation of Estrogenex.

– Indole-3-carbinol – this natural compound is found in many Brassica vegetables, such as Brussels sprouts and kale, for example. In specific doses, Indole-3-carbinol inhibits the action of estrogens and those that cause the development of unwanted female characteristics (such as gynecomastia). Notably, the action of this compound is selective. This ensures that it does not hurt health-promoting types of estrogen. It would therefore not be easy to imagine a compound with a better effect.

– Eurycoma Longifolia (Longjack) (extract standardised to a minimum of 30% glycoproteins) – Longjack belongs to the dedicated group of the most popular plant supplements for men. However, this is no coincidence. The plant has been known for years as an aphrodisiac and fertility-enhancing supplement. This is due, in part, to the fact that the glycoproteins in Longjack have a beneficial effect on male hormonal balance. This, in turn, positively affects both perceived libido and testosterone levels.

– Muira Puama – another well-known plant aphrodisiac is Muira Puama root. Its benefits are primarily related to sexual aspects. Compounds in this root can have a beneficial effect on erectile strength, perceived libido and sexual satisfaction. There are also hypotheses suggesting that this plant has a positive impact on physical endurance levels and testosterone synthesis.

– Quercetin – of all the compounds mentioned so far, quercetin is by far the best known. Athletes often utilise it for its antioxidant properties, which can aid in recovery. However, it is worth noting that quercetin can also help the body maintain proper testosterone levels. This, in turn, sheds a whole new light on this popular compound!

Coumesterol – This compound is found, for example, in soybeans, Brussels sprouts, and spinach. It contains so-called phytoestrogens, which can contribute to hormone regulation in small doses.

– 6′,7′-Dihydroxybergamottin – under this complicated name is a natural compound found, for example, in pomelo fruit and grapefruit. It can increase the absorption of specific nutrients. Thus, its presence in Estrogenex may benefit the overall effectiveness of supplementation.

– Naringenin – another compound isolated from the fruit is naringenin, which shows a beneficial effect on testosterone synthesis in men. The mentioned effect becomes apparent with regular supplementation of this compound. However, it is worth remembering that naringenin will show synergistic effects with other active substances contained in Estrogenex capsules.

Who is it for?

Estrogenex 2nd Generation is ideal for:

• Athletes coming off a cycle are looking for natural estrogen management

• Users aiming to improve testosterone to estrogen ratios

• Individuals stacking with test boosters or DHT-support products

• Those looking to avoid water retention, mood swings, or estrogenic side effects

Not intended for women or individuals under 18.

Dosage – Timing – Follow-Up

Take one tablet 1–3 times per day with meals.
For PCT use, follow a 4–6 week cycle.
Can be stacked with testosterone boosters or liver support formulas.
Do not exceed three tablets per day.

Our opinion

Estrogenex 2nd Generation is a focused, well-constructed product that does more than block aromatase. With a high-quality blend of support compounds and absorption enhancers, it’s a solid choice for anyone looking to regain hormonal control after a heavy cycle or keep estrogen levels in check. Reliable, efficient, and very stackable — an innovative tool for any advanced protocol.

Disclaimer: This product is a dietary supplement and should not be used as a substitute for a varied diet. Do not exceed the recommended daily dose. Keep out of reach of children. If you are pregnant, nursing, taking medication, or have a medical condition, consult your healthcare professional before use. This product contains Aphrodyne and may cause side effects such as increased heart rate, anxiety, or elevated blood pressure. Use with caution and discontinue use if any adverse reactions occur. Store in a cool, dry place away from direct sunlight. The Food and Drug Administration or any other governmental authority has not evaluated the statements made here. This product is not intended to diagnose, treat, cure, or prevent any disease.