SARM – GW-501516 (Cardarine)

Compounds belonging to the group of SARMs may act on many levels. Therefore, the way such substances are classified is relatively conventional. This statement can be illustrated by the example of a compound referred to as GW-501516 or cardarine. Its mechanism of action is why it is often included in the category of SARMs. However, this term is entirely wrong because cardarine acts on completely different receptors. On the other hand, supplementation with this compound can actually be beneficial for active people. So, what properties does GW-501516 have?

GW-501516 SARM – is it really?

Cardarine is often referred to as GW-501516 SARM, which is a colloquial term. However, it is worth correcting a rather important issue.

Cardarine should not be included in the SARMs group at all. The reason is straightforward. The abbreviation SARMs is derived from the substances in this category act – Selective Androgen Receptor Modulators. This means that once they enter the body, they affect the androgen receptors.

GW-501516, on the other hand, works entirely differently. The researchers point out that the compound acts as a PPARδ receptor agonist. Thus it affects completely different receptors than the SARMs.

How was GW-501516 created?

The official name of the manufacturer of cardarine belongs to the British pharmaceutical company GSK (GlaxoSmithKline). However, it is worth noting that the compound was produced in cooperation with Ligand Pharmaceuticals. People who use preparations from the SARMs group should be familiar with this brand. Why? Because Ligand Pharmaceuticals became extremely popular with the invention of the compound LGD-4033, the famous ligandrol. To this day, it remains the most purchased substance of the SARMs group.

But let’s go back to GSK. Reactions occurring in PPARδ receptors are significant for correct metabolic processes. That is why GW-501516 was supposed to be a compound used to treat metabolic disorders and other similar conditions. Clinical studies have shown that cardarine clearly improves lipid metabolism and lowers “bad” cholesterol concentration. Even more interesting were the results of other studies…

The role of cardarine in sport

It is already known that GW-501516 binds to PPARδ receptors and increases their expression. This, in turn, leads to several exciting effects. Researchers first turned their attention to the changes occurring in the body’s lipid metabolism as described above. However, later researchers observed that cardarine can also increase the expression of specific proteins during exercise. Such a discovery very quickly aroused the interest of athletes and physical preparation professionals.

This is because the findings on the properties of cardarine indicated that it is an excellent supplement for active people. On the one hand, GW-501516 increases the body’s exercise capacity through the described enhancement of protein expression. On top of that, cardarine may aid in weight loss due to its improved lipid metabolism. Some reports also mention the potential ability of cardarine to increase insulin sensitivity.

All of the described effects would be very beneficial for professional athletes. Unfortunately, the International Anti-Doping Agency (WADA) has stated that GW-501516 UK will end up on banned substances in professional sports. A similar fate was shared by almost all compounds that are PPARδ receptor modulators. As WADA representatives explained, the use of such preparations could give athletes an unfair advantage over their competitors.

GW-501516 for sale, or cardarine as a dietary supplement

Fortunately, only professional athletes have to comply with these regulations. Others can test the effects of cardarine for themselves. Currently, GW-501516 is a popular ingredient in dietary supplements designed for active people.

An essential advantage of this compound is its very universal properties. Cardarine is helpful for both strength training and aerobic exercise. The increased endurance allows you to perform more prolonged and more intensive training units in both types of activity. This, in turn, has a positive effect on the achieved results.

GW-501516 – Dosage

So far, the properties of cardarine have been tested in various clinical trials. Typically, researchers administered doses of a few milligrams to test subjects. Test results have shown that this amount of cardarine can already provide positive effects. However, among people taking GW-501516 in supplements, doses of 10-15 or even 20 milligrams per day are much more common. Therefore, it will be best to test your body’s reaction to cardarine individually. It is important to note that GW-501516 can be combined with preparations containing compounds from the SARMs group.


Cardarine is a compound mistakenly classified as SARMs because it doesn’t act on androgen receptors but on PPARδ receptors. This affects its properties and benefits of supplementation. The best-studied function of cardarine is its ability to normalize lipid metabolism. In addition, GW-501516 can enhance the expression of specific proteins, which leads to increased endurance throughout the body. Thus, taking cardarine is beneficial for various forms of physical activity. Of course, GW-501516 can only be purchased in supplement form. The recommended daily dose of cardarine is 5-10 milligrams, although some people use doses of 15-20 milligrams per day. So it’s worth tailoring your supplement regimen to your individual needs.