Pure Agmatine 50g is the latest supplement from Koka Labz, agmatine is also known as (4-aminobutyl) guanidine, is a derivative of the amino acid l-arginine.
Agmatine sulfate is a compound that is a metabolite of Agmatine, a substance formed by processing arginine. The human body occurs naturally in the small intestine, liver, adrenal glands or kidneys, and also accumulates in nerve cells. Agmatine is produced in an enzymatic way as a result of bacterial action. It can be found in fermented foods, but its concentration in ingested foods is too low to achieve therapeutic effects. For this reason, agmatine sulfate can be supplied through supplementation.
Characteristics of Agmatine
Agmatine is a biogenic amine composed of one or two positive charges. Its molecule is essential and stable, and its lipophilicity and a high proportion of hydrogen bonds translate into poor absorption. This substance is seen not only as a neurotransmitter but also as a neuromodulator. In the body, Agmatine affects nitric oxide levels as well as the process of blood vessel dilation. This is because this compound blocks nitric oxide synthesis by regulating and inhibiting the main enzymes responsible for its production. Agmatine was first discovered by Albrech Kossel in 1910. As a result of his research, he observed the production of this substance from arginine in a natural fermentation process leading to the decarboxylation of the amino acid. Agmatine sulfate can be produced by humans by converting arginine. Depending on the organ, this process occurs at different intensities.
Biosynthesis and metabolism of Agmatine
L-arginine naturally converts to nitric oxide by secreting it as a byproduct through the action of a synthesis enzyme. On the other hand, Agmatine can affect the metabolism of nitric oxide, but it is not directly converted into it. Its primary metabolic pathways include the enzyme diamine oxidase DAO, which also handles histamine metabolism. During studies in rats, it was discovered that this pathway likely accounts for up to 50 percent of the Agmatine metabolized in the body. The inhibition of the DAO enzyme raises plasma agmatine, most highly expressed in the stomach, intestinal, epithelial, and kidney tissues. It is probably not found in cardiac muscle, skeletal muscle, or the brain. Agmatine can be converted to polyaminoprescin directly through the enzyme agmatinase present in urea as a byproduct. There is also the possibility of conversion to carbamiloputrescin, a byproduct of ammonia, and then to putrescine itself – by the enzyme putrescine transcarbamylase.
Structure of agmatine
Regardless of the metabolic pathway, only about 10 percent of Agmatine is metabolized to polyamines. This substance increases the activity of a protein inhibiting intracellular accumulation of polyamines and their synthesis from ornithine due to inhibition of L-ornithine decarboxylase. This enzyme is induced by the polyamines themselves, whereas Agmatine is the only known molecule to generate a non-polyamine enzyme. Agmatine sulfate is absorbed after oral ingestion, and even low doses increase its concentration in organs. In the systemic circulation, the half-life of this substance is less than 10 minutes. Agmatine cannot be transported across plasma membranes passively and therefore requires the presence of transporters. Uptake into cells is probably mediated by putrescine transporters, high concentrations showing an inhibitory effect on agmatine uptake and vice versa.
Properties of agmatine sulfate
Agmatine sulfate has solid neuroprotective properties, thus supporting the nervous system and protecting it from toxic substances. This compound also has a vasodilatory effect, improving endothelial function and effectively lowering blood pressure. Agmatine sulfate also contributes to increased protein synthesis, and its action on cyclic AMP enhances the process of lipolysis and promotes weight loss. Similar to arginine, this substance accelerates regeneration and takes part in the production of nitric oxide. Stimulating this process promotes the health of the cardiovascular system and minimizes the risk of many diseases. It exhibits antioxidant functions, thus counteracting free radicals that limit the development and proper functioning of cells. Agmatine sulfate dilates blood vessels and increases blood flow, thus improving blood supply and oxygenation of tissues.
Effects of agmatine sulfate
Agmatine sulfate exhibits analgesic effects while sensitizing the body to stimulants. It has a beneficial impact on reducing stress hormones by optimizing cortisol levels. It contributes to an increase in adrenaline and noradrenaline, as well as dopamine. Its use thus improves mood and has an anti-anxiety effect, preventing depression. Agmatine can improve mental performance by increasing concentration and improving many cognitive processes. Due to its properties of expanding psychophysical performance, it is often classified as a nootropic agent. Agmatine sulfate is also used in preventing Alzheimer’s disease, caused by insulin resistance and accumulation of neurofibrillary tangles in the brain. This is because the substance prevents cognitive decline and also improves glycemic.
Agmatine for athletes
Agmatine sulfate is especially valued by athletes because this agent can induce a substantial so-called muscle pump. This is directly due to vasodilation, which leads to improved muscle performance by supplying more blood and nutrients to support muscle building and regeneration. This process occurs with adequate blood supply and oxygenation of muscle tissues, thanks to which their work is optimized even during intensive exercise. Thus, agmatine sulfate can be found in the composition of many pre-training products, which significantly improve the effectiveness and efficiency of athletes.
Dosage:
Take 1-2 grams per day with food. For best results, take 30-60 minutes before your workout.
Taken daily, a reasonable and effective dosage of agmatine recommend for the improvement of mental function would be between 1.6 and 6.4 mg per kilogram of bodyweight.
